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OxyContin tablets should be taken at 12-hourly intervals. The dosage depends on the severity of the pain, and therefore the patient's previous history of analgesic requirements.
Prior to starting treatment with opioids, a discussion should be held with patients to place in situ a technique for ending treatment with oxycodone so as to minimise the danger of addiction and withdrawal syndrome.
Generally, rock bottom effective dose for analgesia should be selected. Increasing severity of pain would require an increased dosage of OxyContin tablets, using the various tablet strengths, either alone or together , to realize pain relief. the right dosage for a person patient is that which controls the pain and is well tolerated for a full 12 hours. Patients should be titrated to pain relief unless unmanageable adverse drug reactions prevent this. If higher doses are necessary, increases should be made in 25% - 50% increments. the necessity for escape medication quite twice each day indicates that the dosage of OxyContin tablets should be increased.
The usual starting dose for opioid naïve patients or patients presenting with severe pain uncontrolled by weaker opioids is 10 mg, 12-hourly. Some patients may enjoy a starting dose of 5 mg to minimise the incidence of side effects. The dose should then be carefully titrated, as frequently as once each day if necessary, to realize pain relief.
Patients receiving oral morphine before OxyContin therapy should have their daily dose supported the subsequent ratio: 10 mg of oral oxycodone is like 20 mg of oral morphine. It must be emphasised that this is often a guide to the dose of OxyContin tablets required. Inter-patient variability requires that every patient is carefully titrated to the acceptable dose.
OxyContin tablets must be administered with caution in patients taking MAOIs or who have received MAOIs within the previous fortnight.
OxyContin tablets shouldn't be used where there's an opportunity of paralytic ileus occurring. Should paralytic ileus be suspected or occur during use, OxyContin tablets should be discontinued immediately.
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OxyContin tablets aren't recommended for pre-operative use or within the primary 12-24 hours post-operatively.
As with all opioid preparations, oxycodone products should be used with caution following abdominal surgery as opioids are known to impair intestinal motility and will not be used until the physician is assured of normal bowel function.
Patients close to undergo additional pain relieving procedures (e.g. surgery, plexus blockade) shouldn't receive OxyContin tablets for 12 hours before the intervention. If further treatment with OxyContin tablets is indicated then the dosage should be adjusted to the new post-operative requirement.
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OxyContin 60 mg, 80 mg and 120 mg tablets shouldn't be utilized in patients not previously exposed to opioids. These tablet strengths may cause fatal respiratory depression when administered to opioid naïve patients.
For appropriate patients that suffer with chronic non-malignant pain, opioids should be used as a part of a comprehensive treatment programme involving other medications and treatment modalities. an important a part of the assessment of a patient with chronic non-malignant pain is that the patient's addiction and drug abuse history.
If opioid treatment is taken into account appropriate for the patient, then the most aim of treatment isn't to minimise the dose of opioid but rather to realize a dose which provides adequate pain relief with a minimum of side effects. There must be frequent contact between physician and patient in order that dosage adjustments are often made. it's strongly recommended that the physician defines treatment outcomes in accordance with pain management guidelines. The physician and patient can then comply with discontinue treatment if these objectives aren't met.